Product Name: Tadalaver
Active substance: Tadalafil
Tadalafil is a selective inhibitor specific phosphodiesterase type 5. As a result of sexual arousal PDE5 leads to increased levels of cGMP in the cavernous body of the penis. As a result, blood flow and occurrence of erection. Tadalaver improves erection that is a prerequisite for making full sexual intercourse. The action of the drug continues for 36 hours, the effect occurs after 16 minutes after taking the drug in the presence of sexual excitement.
Tadalaver does not lead to a significant change in diastolic and systolic blood pressure compared to placebo in supine position (statistical mean a decline of 1.6 / 0.8 mm. Hg. Art. Respectively) and standing (0.2 / 4.6 mm Hg. Art respectively). There are also no reliable known changes in heart rate. There was no effect of Tadalafil on changes color recognition, visual acuity, intraocular pressure and pupil size. Studies have shown that a daily dose of Tadalafil 10 mg had no impact on sperm concentration and motility.
Tadalafil is used to treat male sexual function (impotence or erectile dysfunction). The principle of its action consists in blocking a certain enzyme (phosphodiesterase-PDE5). In combination with sexual stimulation, Tadalaver blood flow in the penis helps. This medicine is only for men. Use of this drug does not protect against sexually transmitted infections (such as HIV, hepatitis B, gonorrhea, syphilis). Practice "safe sex" such as using latex condoms. Consult your doctor or pharmacist for more details.
Contraindications and Cautions:
- Identification of hypersensitivity to any substance that is part of the drug;
- The use of persons under 18 years of age;
- In the case of medication which contain organic nitrates;
- Cialis is not intended for the use of its women.
Most unwanted effects include headache (11%) and dyspepsia (7%). Side effects were minor or moderate severity and decreased in the case of continued use of Cialis. Less severe side effects are back pain, nasal congestion, "surge" of blood to the face, myalgia, even more rarely observed dizziness, eyelid swelling, conjunctive hyperemia, and eye pain.
Tadalaver tablets are taking in, the recommended dose is 20 mg. Medication use in approximately 30 minutes before sexual intercourse regardless of the meal. Effect of Tadalaver lasts 36 hours after ingestion. Need to take Tadalaver once a day. Use of the drug elderly and people suffering from impaired renal or hepatic function For the above-mentioned patients, no special dose adjustment.
The impact of other drugs on Tadalafil
Tadalafil is metabolized under the influence of the enzyme CYP3A4 (ketoconazole), which increases the area under the curve “concentration-time” at 107%, and it reduces rifampicin at 88 %. Specific interactions has not been studied, however, suggests that inhibitors such as saquinavir, ritonavir, CYP3A4, itraconazole and erythromycin lead to increased activity of Tadalafil.
Simultaneous treatment with Tadalafil and antacid leads to a decrease in the rate of absorption of Tadalafil , which has no effect on the changes in the area under concentration-time curve for Tadalafil .
The impact of Tadalafil on other drugs
As a result of the additive effects of nitrates and Tadalafil on the metabolism of nitric oxide is increased hypotensive effect of nitrates. So take Tadalaver with nitrates is contraindicated. Tadalafil has no effect on the pharmacokinetics or pharmacodynamics of the effect of theophylline.
Tadalafil is possible to combine the reception of tools such as angiotensin converting enzyme inhibitors (enalapril), calcium channel blockers (amlodipine), beta- blockers, adrenergic receptors (metoprolol), angiotensin receptor II, antihypertensive agents, alpha- blockers.
The drug cannot be used after the expiry date printed on the package. Store Tadalaver is necessary at a temperature not exceeding 30 degrees Celsius in the reach of children.