Product Name: Metilver
Active substance: Methyltestosterone
Androgen, a synthetic analogue of testosterone. Interacts with specific receptors on the surface cell membrane of cells in the target organs, penetrates into the cytoplasm and nucleus, causing the activation of the genetic apparatus of cells. As the natural hormone stimulates the development of male reproductive organs and secondary sexual characteristics, increases libido and potency, has anabolic effects, the female body - antagonistic action with respect to estrogens. Suppresses the production and release of pituitary LH and FSH. Causes nitrogen retention, Na +, carbonates, phosphates, reduces Ca2 + excretion by the kidneys and promotes its deposition in bones. Controls the growth of long bones (puberty).
Men: hypogonadal hypogonadism, hipogenitalism, impotence and menopause and related vascular and nerve disorders, boys and adolescents: sexual infantilism, retarded growth. Women: dysmenorrhea (in menopause period), inoperable breast cancer in post-menopausal, ovarian cancer.
Contraindications and Cautions:
Hypersensitivity, carcinoma of the breast, prostate cancer, severe liver and / or renal failure, hypercalcemia, pregnancy, puberty age. Arterial hypertension, chronic heart failure, epilepsy, migraine.
On the part of the endocrine system: women - virilization symptoms (hirsutism, alopecia, irreversible deepening of the voice, menstrual irregularities, suppression of ovarian function, enlargement of the clitoris), acne rash, men - gynecomastia, oligospermia, painful erection. The nervous system: dizziness, headache, generalized paresthesia, anxiety, and depression. From the digestive system: dyspeptic symptoms (nausea, vomiting, diarrhea and abdominal pain), hepatocellular carcinoma, cholestasis, cholestatic hepatitis. Other: edema (delay of Na + in the body), increased bleeding, thrombophlebitis, hypercalcemia, hyperlipidemia, increased libido, allergic reaction. In case of signs of virilization shows removal of the drug.
The dose and duration of treatment are set individually depending on the evidence, the clinical picture and the severity of the disease, and the effectiveness of the therapy. Males and at eunuchoidism gipogenitalizme administered sublingually, 10-30 mg daily or every other day, for a long time. When impotence - 10-20 mg / day. When the male menopause - at 5-15 mg for 1-2 months. At a delay of sexual development, infantilism, growth retardation in children - 5-10 mg / day. In women with dysfunctional uterine bleeding dose is 10-20 mg / day in one phase of the cycle for 10-14 days. In breast cancer and ovarian dose is 50-100 mg / day. The maximum single dose - 50 mg maximum daily dose - 100 mg.
When applied simultaneously increases the effects of anticoagulants and hypoglycemic drugs. The androgenic activity of the drug reduces the barbiturates, cimetidine, parathyroidin.
Keep at room temperature, 15 to 30 C, away from heat, sun and moisture.