Product Name: Clomiver
Active substance: Clomiphene Citate
Non-steroidal anti-estrogenic drug structure. Stimulates ovulation. It is assumed that Clomiphene Citrate blocking estrogen receptors in the hypothalamus and ovaries and through feedback, enhances the secretion of the pituitary gonadotropins, especially LH. This, in turn, excites the maturation and action of the endocrine ovarian follicles and the following creation and functioning of yellow corpus.
The active substance of Clomiver - Clomiphene Citrate- after ingestion is rapidly absorbed from the gastrointestinal tract. After five day the use of 5-Clomiver its cumulative excretion was 50% of the highest dose (urine - 7.8% in feces - 42.2%). 31-35th day of treatment with urine and feces daily output by 0.73% of the dose, and the 42-45th day of treatment - 0.54% respectively.
Stimulation of ovulation in women with infertility due to secondary hypothyroidism ovaries, mainly due to functional hypothalamic-pituitary disorders.
Contraindications and Cautions:
Before the appointment of the preparation is carried out survey of patients in order to exclude malignant tumors of the uterus or breast cancer, ovarian cysts, or increase (Stein-Leventhal syndrome is not a contraindication for prescribing) and other diseases in which the use of Clomiver is contraindicated.
It will be appreciated that the drug is more effective as a sufficient level of endogenous estrogen is less effective at low estrogen and practically ineffective at low pituitary gonadotropins. Treatment performed using the lowest effective doses. Not recommended for more than 6 courses. The treatment is carried out careful monitoring of the patient carefully monitored for signs of the appearance of pregnancy. It should be borne in mind that often occurs during pregnancy cycle, following the lifting of the drug. Gynecological examination to rule out an abnormal increase in ovarian conduct and before each subsequent course of treatment. Patients should be advised to promptly report to your doctor about the appearance of pain in the abdomen, as well as an increase in body weight.
In case of any during treatment of pain in the abdomen conduct a thorough examination of the patient and, if there is an increase of ovarian, treatment should be stopped until the normalization of the size of the ovaries. Dose and duration of its use during the next frame in such cases is reduced. In the case of repeated violations of the drug is not prescribed. After successful treatment with an increased incidence of multiple pregnancy. Do not use this product in the following cases:
• Uterine bleeding of unknown etiology;
• Malignant neoplasm of uterine or breast cancer;
• Contraindications in pregnancy;
• Ovarian cyst (except polycystic), endometriosis;
• Primary ovarian dysfunction;
• Hypersensitivity to any components of the preparation.
• Ovarian failure on the background of hyperprolactinemia;
On the part of the ovaries and endocrine status: transitory rise in the ovaries, supplemented by discomfort or pain in the abdomen, increased breast tenderness, "tides" of blood to the face. Part of the vision: transient disturbances in the form of blurry vision, shimmering cattle, functional retinal changes enforced by electroretinography.
Of the liver: a delay launch bromsulfaleina, jaundice (in rare cases).
Dermatological reactions: atopic dermatitis, reversible alopecia.
Other: nausea, vomiting, irritability, insomnia, headache, dizziness, fatigue.
Measuring mode: Clomiver is administered at a dose of 50 mg 1 time / day (after meals). The period of cure is 5 days (from the 5th to the 9th day of the menstrual cycle). In the absence of the estimated result in about 30 days after the end of the first course, a second 5-five day course of treatment, appointing 50 mg 2 times / day.
Even better effects are realized when Clomiphene Citrate combined with HCG or when Clomiphene Citrate is taken subsequently the use of drugs HCG. The difference between Clomiphene Citrate and HCG that Clomiphene Citrate has a direct effect on the hypothalamus and pituitary and triggers the complete reflex arc, while HCG rises the result of luteinizing hormone, which in turn excites the testicular germ cells for greater production of testosterone. Since HCG unlike Clomiphene Citrate had a few hours after taking it considerably growths the level of testosterone, many athletes first take HCG and lastly Clomiphene Citrate.
Store in a dry, dark place at a temperature not exceeding 25 ° C.